Clinical Inquiries, 2019

 

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Recent Submissions

  • Does using e-cigarettes cigarette smoking in adolescents? 

    Asher, Tim; Belden, Jenna Leah; Kelsbert, Gary; Safranek, Sarah (Family Physicians Inquiries Network, 2019)
    Q: Does using e-cigarettes cigarette smoking in adolescents? Evidence-based answer: Probably. Electronic cigarette (e-cigarette) use by adolescents is associated with a 2- to 4-fold increase in cigarette smoking over the ...

  • Does tranexamic acid reduce mortality in women with postpartum hemorrhage? 

    Dresang, Lee; Kredit, Sheila; Vellardita, Lia (Family Physicians Inquiries Network, 2019)
    Q: Does tranexamic acid reduce mortality in women with postpartum hemorrhage? EVIDENCE-BASED ANSWER: Yes. When used in conjunction with the standard of care, 1 g intravenous (IV) tranexamic acid given 1 to 3 hours after ...

  • Time to conception after miscarriage : how long to wait? 

    Farahi, Narges; Mounsey, Anne; Auten, Beth (Family Physicians Inquiries Network, 2019)
    Q: Time to conception after miscarriage: how long to wait? Evidence-based answer: an interpregnancy interval (IPI) of < 6 months following miscarriage is associated with an increased live birth rate in subsequent pregnancy, ...

  • How safe and effective is ondansetron for nausea and vomiting in pregnancy? 

    Collins, Kimberly L.; Wilson, Megan; Vincent, E. Chris; Safranek, Sarah (Family Physicians Inquiries Network, 2019)
    Q: How safe and effective is ondansetron for nausea and vomiting in pregnancy? Evidence-based answer: oral ondansetron is more effective than a combination of pyridoxine and doxylamine for outpatient treatment of nausea ...

  • Which oral nonopioid agents are most effective for OA pain? 

    Gilmer, Benjamin; Hulkower, Stephen; Wilson, Courtenay Gilmore; Macdonald, Brittney; Pozner, Jonathan; Stigleman, Sue (Family Physicians Inquiries Network, 2019)
    Q Which oral nonopioid agents are most effective for OA pain? Evidence-based answer: nonsteroidal anti-inflammatory drugs (nsaids), when used at the maximum clinically effective dose, reduce osteoarthritis (OA) pain in ...

  • Do A-fib patients continue to benefit from vitamin K antagonists with advancing age? 

    Guthmann, Richard; Bahrami, Azita; Martin, Robert; Nashelsky, Joan (Family Physicians Inquiries Network, 2019)
    Q Do A-fib patients continue to benefit from vitamin K antagonists with advancing age? Evidence-based answer: yes, patients with atrial fibrillation who are between the ages of 50 and 90 years continue to benefit from ...

  • Can unintended pregnancies be reduced by dispensing a year's worth of hormonal contraception? 

    Wirsing, Nellie; Pierce, Carrie; Nashelsky, Joan (Family Physicians Inquiries Network, 2019)
    Q. Can unintended pregnancies be reduced by dispensing a year's worth of hormonal contraception? Evidence-based answer: probably, although studies that looked directly at this outcome are limited. A systematic review showed ...

  • How effective is spironolactone for treating resistant hypertension? 

    Lyon, Corey; Utter, Brigitte; DeSanto, Kristen (Family Physicians Inquiries Network, 2019)
    Q: How effective is spironolactone for treating resistant hypertension? EVIDENCE-BASED ANSWER: VERY EFFECTIVE. Spironolactone reduces systolic blood pressure (SPB) by 11 to 17 mm Hg and diastolic blood pressure (DPB) by ...

  • Does withholding an ACE inhibitor or ARB before surgery improve outcomes? 

    Jackman, Robert; Hamilton, Andrew (Family Physicians Inquiries Network, 2019)
    Q: Does withholding an ACE inhibitor or ARB before surgery improve outcomes? EVIDENCE-BASED ANSWER: A GUARDED YES, because the evidence of benefit is from observational studies and applies to noncardiac surgery. Withholding ...

  • What are the risks of long-term PPI use for GERD symptoms in patients > 65 years? 

    Devitt, Jessica; Lyon, Corey; Swanson, Sarah Beth; DeSanto, Kristen (Family Physicians Inquiries Network, 2019)
    Q: What are the risks of long-term PPI for GERD symptoms in patients > 65 years? EVIDENCE-BASED ANSWER: THE USE OF PROTON PUMP INHIBITORS (PPIs) to control gastrointestinal esophageal reflux disease (GRED) is significantly ...

  • Is intra-articular platelet-rich plasma injection an effective treatment for knee OA? 

    Wilcox, Carrie Lynn; Safranek, Sarah (Family Physicians Inquiries Network, 2019)
    Q: Is intra-articular platelet-rich plasma injection an effective treatment for knee OA? EVIDENCE-BASED ANSWER: PROBABLY NOT, based on the balance of evidence. While low-quality evidence may suggest potential benefit, the ...

  • Does left atrial appendage closure reduce stroke rates as well as oral anticoagulants and antiplatelet meds in A-fib patients? 

    Careyva, Beth; Keister, Drew; Mathieu, Susan; Wilson, Lynn; Nashelsky, Joan (Family Physicians Inquiries Network, 2019)
    Q: Does left atrial appendage closure reduce stroke rates as well as oral anticoagulants and antiplatelet meds in A-fib patients? EVIDENCE-BASED ANSWER: Yes. Left atrial appendage closure (LAAC) with the Watchman device ...