Devices and Materials in the Continuous Monitoring of Metabolites
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The importance and need for continuous monitoring of metabolites cannot be overemphasized. Most recent developments for in vivo monitoring devices have focused on miniaturization and the exploratory use of new functional materials. As most biosensors tend to drift and degrade over time, the development of a simple, dependable, on-demand, in situ (and possibly in vivo) self-calibration/self-diagnosis technique is a key obstacle for convenient, continuous monitoring with minimum intervention. The availability of this "weak link" would greatly improve the reliability and convenience of continuous monitoring technology. Work at Missouri S&T addresses these issues and provides solutions toward reliable and continuous monitoring of metabolites (glucose, lactate, etc.) with minimal human attendance using either optical or electrochemical detection methods.