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dc.contributor.advisorSmith, Charles J. (Charles Jeffrey), 1969-eng
dc.contributor.advisorJurisson, Silvia S. (Silvia Sabine)eng
dc.contributor.authorLane, Stephanie R., 1982-eng
dc.date.issued2009eng
dc.date.submitted2009 Falleng
dc.descriptionTitle from PDF of title page (University of Missouri--Columbia, viewed on Feb 24, 2010).eng
dc.descriptionThe entire thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file; a non-technical public abstract appears in the public.pdf file.eng
dc.descriptionDissertation advisor: Professor Silvia S. Jurisson and Professor Charles J. Smith.eng
dc.descriptionVita.eng
dc.descriptionPh. D. University of Missouri--Columbia 2009.eng
dc.description.abstractAn active area of prostate cancer research is in the synthesis of radiolabeled peptides for in vivo tumor imaging or therapy. This method is possible since specific receptors are expressed in high concentration on certain tumor tissue. One receptor that is expressed in high concentration on prostate cancer tissue is the gastrin-releasing peptide (GRP). The amphibian peptide, bombesin (BBN), has high affinity and specificity to the GRP receptors; therefore, when BBN is radiolabeled with an appropriate radionuclide, non-invasive prostate tumor images and therapy can be obtained. The aim of this research was to produce kinetically inert bifunctional chelate complexes that would effectively contain the radionuclide Rhenium-188 ([superscript 188]Re), Technetium-99m ([superscript 99][superscript-m]Tc), Copper-64 ([superscript 64 ]Cu) or Bismuth-213 ([superscript 213]Bi).eng
dc.description.bibrefIncludes bibliographical referenceseng
dc.format.extentxvii, 184 pageseng
dc.identifier.oclc605908344eng
dc.identifier.urihttps://hdl.handle.net/10355/6851
dc.identifier.urihttps://doi.org/10.32469/10355/6851eng
dc.languageEnglisheng
dc.publisherUniversity of Missouri--Columbiaeng
dc.relation.ispartofcommunityUniversity of Missouri--Columbia. Graduate School. Theses and Dissertationseng
dc.rightsOpenAccess.eng
dc.rights.licenseThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 License.
dc.subject.lcshProstate -- Cancer -- Radionuclide imagingeng
dc.subject.lcshBombesineng
dc.subject.lcshRadiopharmaceuticalseng
dc.titleProspective radiolabled bombesin conjugates for prostate cancer imaging and therapeutic agentseng
dc.typeThesiseng
thesis.degree.disciplineChemistry (MU)eng
thesis.degree.grantorUniversity of Missouri--Columbiaeng
thesis.degree.levelDoctoraleng
thesis.degree.namePh. D.eng


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