dc.contributor.advisor | Smith, Charles J. (Charles Jeffrey), 1969- | eng |
dc.contributor.advisor | Jurisson, Silvia S. (Silvia Sabine) | eng |
dc.contributor.author | Lane, Stephanie R., 1982- | eng |
dc.date.issued | 2009 | eng |
dc.date.submitted | 2009 Fall | eng |
dc.description | Title from PDF of title page (University of Missouri--Columbia, viewed on Feb 24, 2010). | eng |
dc.description | The entire thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file; a non-technical public abstract appears in the public.pdf file. | eng |
dc.description | Dissertation advisor: Professor Silvia S. Jurisson and Professor Charles J. Smith. | eng |
dc.description | Vita. | eng |
dc.description | Ph. D. University of Missouri--Columbia 2009. | eng |
dc.description.abstract | An active area of prostate cancer research is in the synthesis of radiolabeled peptides for in vivo tumor imaging or therapy. This method is possible since specific receptors are expressed in high concentration on certain tumor tissue. One receptor that is expressed in high concentration on prostate cancer tissue is the gastrin-releasing peptide (GRP). The amphibian peptide, bombesin (BBN), has high affinity and specificity to the GRP receptors; therefore, when BBN is radiolabeled with an appropriate radionuclide, non-invasive prostate tumor images and therapy can be obtained. The aim of this research was to produce kinetically inert bifunctional chelate complexes that would effectively contain the radionuclide Rhenium-188 ([superscript 188]Re), Technetium-99m ([superscript 99][superscript-m]Tc), Copper-64 ([superscript 64 ]Cu) or Bismuth-213 ([superscript 213]Bi). | eng |
dc.description.bibref | Includes bibliographical references. | eng |
dc.format.extent | xvii, 184 pages | eng |
dc.identifier.oclc | 605908344 | eng |
dc.identifier.uri | https://hdl.handle.net/10355/6851 | |
dc.identifier.uri | https://doi.org/10.32469/10355/6851 | eng |
dc.language | English | eng |
dc.publisher | University of Missouri--Columbia | eng |
dc.relation.ispartofcommunity | University of Missouri--Columbia. Graduate School. Theses and Dissertations | eng |
dc.rights | OpenAccess. | eng |
dc.rights.license | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 License. | |
dc.subject.lcsh | Prostate -- Cancer -- Radionuclide imaging | eng |
dc.subject.lcsh | Bombesin | eng |
dc.subject.lcsh | Radiopharmaceuticals | eng |
dc.title | Prospective radiolabled bombesin conjugates for prostate cancer imaging and therapeutic agents | eng |
dc.type | Thesis | eng |
thesis.degree.discipline | Chemistry (MU) | eng |
thesis.degree.grantor | University of Missouri--Columbia | eng |
thesis.degree.level | Doctoral | eng |
thesis.degree.name | Ph. D. | eng |