The type I IFN of Bos taurus

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The type I IFN of Bos taurus

Please use this identifier to cite or link to this item: http://hdl.handle.net/10355/6864

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dc.contributor.advisor Roberts, R. M. (Robert Michael), 1940- en_US
dc.contributor.author Walker, Angela Marie, 1978- en_US
dc.date.accessioned 2010-04-19T14:39:19Z
dc.date.available 2010-04-19T14:39:19Z
dc.date.issued 2008 en_US
dc.date.submitted 2008 Spring en_US
dc.identifier.other WalkerA-110509-D9687 en_US
dc.identifier.uri http://hdl.handle.net/10355/6864
dc.description The entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file. en_US
dc.description Title from PDF of title page (University of Missouri--Columbia, viewed on April 1, 2010). en_US
dc.description Includes bibliographical references en_US
dc.description Vita. en_US
dc.description Thesis advisor: R. Michaels Roberts. en_US
dc.description "May 2008" en_US
dc.description Ph. D. University of Missouri-Columbia 2008. en_US
dc.description Dissertations, Academic -- University of Missouri--Columbia -- Veterinary pathobiology area program. en_US
dc.description.abstract The Type I interferons (IFN) have major roles in the innate immune response to viruses, a function that is believed to have led to rapid expansion in the number and complexity of their genes. IFNT, which is a unique Type I IFN restricted to pecoran ruminants, also has a specialized role in maternal recognition of pregnancy in cattle. This work has two main aims 1) determine whether male and female blastocysts differ in the kind and number of IFNT they express and whether this pattern changes over development and 2) provide the first comprehensive annotation of the Type I IFN locus in Bos taurus, thereby providing an insight into the functional evolution of the Type IFN in ruminants. Data collected for the first aim indicate that female blastocysts do not transcribe a different set of IFNTs than males (p=0.54). However, significant differences (p < 0.001) were evident among conceptuses of different age, indicating that additional genes may be transcribed as IFNT production increases during development. The data collected for the second aim revealed the Type I IFN locus has undergone significant rearrangement and expansion in bovine compared to mouse and human. The IFNW subfamily is greatly expanded compared to other species, comprising 24 potentially functional genes. Selective pressure analysis found the regulatory regions of the IFNW are diverging faster than the coding regions. The identification of a new Type I IFN subfamily that is expressed from virally challenged bovine kidney cells is the most striking finding of the second aim. en_US
dc.format.extent xi, 177 pages en_US
dc.language.iso en_US en_US
dc.publisher University of Missouri--Columbia en_US
dc.relation.ispartof 2008 Freely available dissertations (MU) en_US
dc.subject.lcsh Interferon -- Metabolism -- Genetic aspects en_US
dc.subject.lcsh Blastocyst en_US
dc.subject.lcsh Cattle -- Genetics en_US
dc.subject.lcsh Genetic transcription en_US
dc.subject.lcsh Interferon -- Evolution en_US
dc.subject.lcsh Molecular evolution en_US
dc.title The type I IFN of Bos taurus en_US
dc.type Thesis en_US
thesis.degree.discipline Veterinary pathobiology area program en_US
thesis.degree.grantor University of Missouri--Columbia en_US
thesis.degree.name Ph. D. en_US
thesis.degree.level Doctoral en_US
dc.identifier.oclc 605037785 en_US
dc.relation.ispartofcommunity University of Missouri-Columbia. Graduate School. Theses and Dissertations. Dissertations. 2008 Dissertations


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