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dc.contributor.advisorRoberts, R. M. (Robert Michael), 1940-en_US
dc.contributor.authorWalker, Angela Marie, 1978-en_US
dc.date.issued2008eng
dc.date.submitted2008 Springen_US
dc.descriptionThe entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file.en_US
dc.descriptionTitle from PDF of title page (University of Missouri--Columbia, viewed on April 1, 2010).en_US
dc.descriptionIncludes bibliographical referencesen_US
dc.descriptionVita.en_US
dc.descriptionThesis advisor: R. Michaels Roberts.en_US
dc.description"May 2008"en_US
dc.descriptionPh. D. University of Missouri-Columbia 2008.en_US
dc.descriptionDissertations, Academic -- University of Missouri--Columbia -- Veterinary pathobiology area program.en_US
dc.description.abstractThe Type I interferons (IFN) have major roles in the innate immune response to viruses, a function that is believed to have led to rapid expansion in the number and complexity of their genes. IFNT, which is a unique Type I IFN restricted to pecoran ruminants, also has a specialized role in maternal recognition of pregnancy in cattle. This work has two main aims 1) determine whether male and female blastocysts differ in the kind and number of IFNT they express and whether this pattern changes over development and 2) provide the first comprehensive annotation of the Type I IFN locus in Bos taurus, thereby providing an insight into the functional evolution of the Type IFN in ruminants. Data collected for the first aim indicate that female blastocysts do not transcribe a different set of IFNTs than males (p=0.54). However, significant differences (p < 0.001) were evident among conceptuses of different age, indicating that additional genes may be transcribed as IFNT production increases during development. The data collected for the second aim revealed the Type I IFN locus has undergone significant rearrangement and expansion in bovine compared to mouse and human. The IFNW subfamily is greatly expanded compared to other species, comprising 24 potentially functional genes. Selective pressure analysis found the regulatory regions of the IFNW are diverging faster than the coding regions. The identification of a new Type I IFN subfamily that is expressed from virally challenged bovine kidney cells is the most striking finding of the second aim.en_US
dc.format.extentxi, 177 pagesen_US
dc.identifier.oclc605037785en_US
dc.identifier.otherWalkerA-110509-D9687en_US
dc.identifier.urihttp://hdl.handle.net/10355/6864
dc.publisherUniversity of Missouri--Columbiaen_US
dc.relation.ispartof2008 Freely available dissertations (MU)en_US
dc.relation.ispartofcommunityUniversity of Missouri-Columbia. Graduate School. Theses and Dissertations. Dissertations. 2008 Dissertations
dc.subject.lcshInterferon -- Metabolism -- Genetic aspectsen_US
dc.subject.lcshBlastocysten_US
dc.subject.lcshCattle -- Geneticsen_US
dc.subject.lcshGenetic transcriptionen_US
dc.subject.lcshInterferon -- Evolutionen_US
dc.subject.lcshMolecular evolutionen_US
dc.titleThe type I IFN of Bos taurusen_US
dc.typeThesisen_US
thesis.degree.disciplineVeterinary pathobiology area programen_US
thesis.degree.disciplineVeterinary pathobiology area programeng
thesis.degree.grantorUniversity of Missouri--Columbiaen_US
thesis.degree.levelDoctoralen_US
thesis.degree.namePh. D.en_US


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