dc.contributor.advisor | Smolderen, Kim G. | |
dc.contributor.author | Khariton, Yevgeniy | |
dc.date.issued | 2018 | |
dc.date.submitted | 2018 Spring | |
dc.description | Title from PDF of title page viewed June 14, 2019 | |
dc.description | Thesis advisor: Kim Smolderen | |
dc.description | Vita | |
dc.description | Includes bibliographical references (pages 39-46) | |
dc.description | Thesis (M.S.)--School of Medicine. University of Missouri--Kansas City, 2018 | |
dc.description.abstract | Objective: The ACC/AHA cholesterol guidelines recommend patients with peripheral artery
disease (PAD) be treated with a moderate to high-intensity statin. The extent to which PAD
patients with new or worsening claudication symptoms are offered guideline statin therapy is
unknown.
Methods: In the PORTRAIT registry, patterns of statin therapy were assessed in 1144 patients
at 16 PAD specialty clinics (between June 2011-December 2015) before and after an
evaluation for new or worsening claudication symptoms. It was documented whether patients
had been previously treated with a guideline-directed statin as well as switched from non
guideline to guideline statin therapy. Patient factors predicting intensification to guideline
statin were examined. Site and provider-level variation in guideline statin intensification were
summarized by calculating median odds ratios.
Results: Among 1144 patients, 810 (70.8%) were initially on guideline therapy compared with
334 (29.2%) that were not. In the latter, 103 (30.8%) were prescribed guideline therapy after
evaluation. Patients with typical symptoms displayed greater odds of intensification to
guideline statin (OR 3.75; 95% CI: 1.22-11.53) while older patients had lower odds (OR
0.60/decade; 95% CI: 0.40-0.87). Variability in guideline statin intensification was observed
across sites (Adjusted Median Odds Ratio = 3.63; 95% CI 1.88-5.42, (p <0.05)) but not
providers (Adjusted Median Odds Ratio = 1.90; 95% CI 1.00-2.55, (p >0.05)).
Conclusions: In conclusion, most patients evaluated at a PAD specialty clinic for new or
worsening claudication symptoms arrived on a guideline-directed statin. Only 31% originally
off guideline therapy were intensified to a guideline statin. These findings highlight an
important opportunity to optimize medical therapy for patients with PAD. | eng |
dc.description.tableofcontents | Introduction -- Methods -- Results -- Discussion -- Tables and figures -- SAS syntax | |
dc.format.extent | x, 47 pages | |
dc.identifier.uri | https://hdl.handle.net/10355/68865 | |
dc.publisher | University of Missouri -- Kansas City | eng |
dc.subject.lcsh | Statins (Cardiovascular agents) | |
dc.subject.lcsh | Peripheral vascular diseases | |
dc.subject.mesh | Hydroxymethylglutaryl-CoA Reductase Inhibitors | |
dc.subject.mesh | Peripheral Arterial Disease | |
dc.subject.other | Thesis -- University of Missouri--Kansas City -- Medicine | |
dc.title | Guideline-Directed Statin Therapy in Patients with New or Worsening Symptoms of Peripheral Artery Disease | eng |
dc.type | Thesis | eng |
thesis.degree.discipline | Bioinformatics (UMKC) | |
thesis.degree.grantor | University of Missouri--Kansas City | |
thesis.degree.level | Masters | |
thesis.degree.name | M.S. (Master of Science) | |