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dc.contributor.advisorLubahn, Dennis B.eng
dc.contributor.authorLi, Yufeieng
dc.date.issued2018eng
dc.date.submitted2018 Summereng
dc.description.abstract3,3'- diindolylmethane (DIM) is an acid -derived compound formed during the digestion of indole-3-carbinol (I3C), which is one of the main compounds in cruciferous vegetables, such as broccoli, cabbage and kale. Studies indicate that the cancer protective effects of cruciferous vegetables and I3C partially rely on DIM, which is the bioactive form of I3C in the body, and DIM has been shown to interact with several signaling pathways in cancer. However, the primary molecular working mechanism of DIM is still not clear. In this dissertation, we hypothesize that DIM works through estrogen receptor (ER) signaling to inhibit prostate cancer. We focus on DIM's interaction with ER, as well as its effects on preventing advanced prostate cancer and weight gain in the TRansgenic Adenocarcinoma of Mouse Prostate (TRAMP) model.eng
dc.description.bibrefIncludes bibliographical referenceseng
dc.format.extentxiii, 122 pages : illustrationseng
dc.identifier.urihttps://hdl.handle.net/10355/69862
dc.languageEnglisheng
dc.publisherUniversity of Missouri--Columbiaeng
dc.relation.ispartofcommunityUniversity of Missouri--Columbia. Graduate School. Theses and Dissertationseng
dc.rightsOpenAccesseng
dc.rights.licenseThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Licenseeng
dc.titleCharacterization of the effects of 3,3'-diindolylmethane (DIM) in the TRAMP mouse prostate cancer model and DIM's interaction with estrogen receptor signalingeng
dc.typeThesiseng
thesis.degree.disciplineBiochemistry (MU)eng
thesis.degree.grantorUniversity of Missouri--Columbiaeng
thesis.degree.levelDoctoraleng
thesis.degree.namePh. D.eng


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