RSS 1.0Department of Radiology (MU)
Radiolgical sciences are based on physical and biological sciences and complement the basic sciences taught in medical school. Faculty of the Department of Radiology investigate various physical, chemical and biological systems. Specific research areas include radiopharmaceutical development, investigation of new radioactive drugs for therapy and diagnosis, and the development of new imaging systems.
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An Effective Strategy for the Synthesis of Biocompatible Gold Nanoparticles Using Cinnamon Phytochemicals for Phantom CT Imaging and Photoacoustic Detection of Cancerous Cells
(Pharmaceutical Research, 2011)Purpose: The purpose of the present study was to explore the utilization of cinnamon coated gold nanoparticles (Cin-AuNPs) as CT/optical contrast enhancement agent for detection of cancer cells. Methods: Cin-AuNPs were ... -
Gastrin Releasing Protein Receptor Specific Gold Nanorods: Breast and Prostate Tumor Avid Nanovectors for Molecular Imaging
(American Chemical Society, 2009)Gastrin releasing protein receptor specific bombesin (BBN) peptide-gold nanoconjugates were successfully synthesized using gold nanorods and dithiolated peptide. The gold nanorod-bombesin (GNR-BBN) conjugates showed ... -
Agarose-stabilized gold nanoparticles for surface-enhanced Raman spectroscopic detection of DNA nucleosides
(American Institute of Physics, 2006)We present surface-enhanced Raman scattering (SERS) studies of DNA nucleosides using biologically benign agarose-stabilized gold nanoparticles (AAuNP). We compare the SERS activity of nucleosides with AAuNP to that of ... -
A Comparative Study between Antibody and Peptide Conjugated Gold Nanoparticles for In Vivo Targeting of EGFR in Pancreatic Cancer Bearing Mice Models [abstract]
(2010-03)Pancreatic cancer is the fourth leading cause of cancer related deaths in the United States due to its severe aggressiveness and lethal malignancy. Epidermal Growth Factor Receptor (EGFR) is over expressed in more than 95% ... -
Development of Absorption and Fluorescence Probes Based on Mouse Model for Molecular Optical Imaging [abstract]
(2010)In this work we summarize our collaborative research on a project to develop absorption and fluorescence targeting probes. Several groups from University of Missouri and Harry S. Truman Memorial Veteran's Hospital including ... -
Early Breast Cancer Detection Using Fluorescence Mediated Tomographic Imaging [abstract]
(2010)Development of reliable technologies for early detection and screening of breast cancer is significant since the overall accuracy of traditional mammography remains low for diagnosis of benign and malignant lesions. In ... -
A Novel Method to Monitor Sequential Displacement of Capped Ligands in Gold Nanoparticles [abstract]
(2010-02)Nanochemistry of ligand displacement reactions has attracted much attention in recent years for the development of myriad of new gold nanomaterials. Gold nanoparticles have shown applications ranging from tumor imaging ... -
Photoacoustic Detection of Circulating Prostate, Breast and Pancreatic Cancer cells using targeted Gold Nanoparticles: Implications of Green Nanotechnology in Molecular Imaging
(2010-02)Circulating tumor cells are hallmarks of metastasis cancer. The presence of circulating tumor cells in blood stream correlates with the severity of disease. Photoacoustic imaging (PA) of tumor cells is an attractive technique ... -
Creation of 'Super Avastin': A New Nanomedicine Approach for the Treatment of PXE and AMD [abstract]
(2010-02)Nanomedicine is an emerging medical area that utilizes nanoparticles for the detection and treatment of diseases. The ubiquitous place of gold in Nanomedicine stems from its chemical ability to serve in an unoxidized state ... -
Comparative oncology and clinical translation of glyco protein conjugated gold nano therapeutic agent (GA-198AuNP) [abstract]
(2010)As part of our efforts toward clinical translation of GA-198AuNP, our studies are focused on therapeutic efficacy of nanoparticulate GA198AuNP agent in dogs with prostatic carcinoma. The overall goal is to gain clinical ... -
Clinical Translation of Nanopharmaceuticals for Cancer Therapy [abstract]
(2010-02)The most recent study involving 77,000 North American men has shown that regular prostate specific antigen (PSA) screening did not provide accurate diagnosis of prostate cancer and therefore did not save lives of cancer ... -
Experiences in Patenting, Licensing and Commercialization of Radiopharmaceuticals
(2010-02)This presentation will highlight successful efforts in working with the UM Office of Patents and Licensing to patent, license and commercialize radiopharmaceuticals for medical applications that emerged from collaborative ...