UMKC SWORD
Recent Submissions
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DELIVERY OF STING AGONIST USING LIPID NANOPARTICLES AND DISCOVERY OF ANTI-TIGIT PEPTIDES FOR CANCER THERAPY
(2023)Over the past decades, cancer treatment has significantly advanced with the approval of new therapeutic entities aimed at treating this disease. However, these advancements have not universally benefitted all patients or ... -
Bearing Witness: Essays, Stories, And A Novel In Progress
(2023)Storytelling is like the air that we breathe. We need the stories to thrive, to be enriched, and to grow like the plants and animals around us. Stories are the places where we are rooted. And to tell a story is to bear ... -
Mutterrecht to Mauerfall: Cassandra and Penthesilea in 1980s East German Art
(2023)Two important mythological figures emerged in East German art in the 1980s: Cassandra, the Trojan prophetess, and Penthesilea, the Amazon warrior queen. Christa Wolf’s 1983 novel, Cassandra, exerted a profound influence ... -
Exploring Multivalency and Chemical Modifications in the Development of Anti-PD-L1 Peptide Inhibitors for Cancer Immunotherapy
(2023)The PD-1/PD-L1 immune checkpoint axis is one of the most common pathways exploited by cancers to evade immune surveillance. Many cancers overexpress PD-L1 (programmed cell death ligand 1) on their surface through which ... -
Discovery of IKBKE and CD24 siRNAs for the Treatment of Triple-Negative Breast Cancer
(2023)Triple-negative breast cancer (TNBC) represents approximately 10-20% of all newly diagnosed breast cancers and is classified as a subtype with the absence of ER, PR, and HER2 expression. TNBC displays high aggressiveness, ... -
Investigation of Process–Structure–Property Correlations for Plasma-Enhanced Chemical Vapor Deposited Complex Disordered Solids: Towards Data-Driven Computational Materials Design
(2023)Complex disordered solids, characterized by multicomponent, multiphase, sub-structured configurations, coupled with a lack of long-range order, represent an application-rich class of materials, exhibiting a vast number of ... -
Targeting Extracellular Matrix Using siRNA for the Treatment of Liver Fibrosis and Pancreatic Cancer
(2023)The objective of this dissertation is to develop peptide-based siRNA delivery systems for the treatment of liver fibrosis and pancreatic ductal adenocarcinoma (PDAC). We recently discovered that silencing the poly (rC) ... -
MITIGATING ANTIBIOTIC-RESISTANT PATHOGENS: A MULTIFACETED STRATEGY FOR NOVEL ANTIBACTERIAL DRUG DEVELOPMENT AND COMPREHENSIVE LCMS/MS APPLICATIONS FOR DIVERSE THERAPEUTIC ADVANCEMENTS
(2023)In response to the escalating threat of antimicrobial resistance, our study adopted a multifaceted strategy to combat antibiotic-resistant pathogens. The initial phase involved the screening of the GSK TB box set against ... -
IDENTIFICATION AND ASSESSMENT OF PEPTIDES AND SINGLE DOMAIN ANTIBODIES FOR CANCER THERAPY
(2023)The discovery of immune checkpoint inhibitors has revolutionized cancer therapy. These immune checkpoint inhibitors suppress tumor growth by immune checkpoint blockade. This approach involves blocking inhibitory immune ... -
Investigation of Electrically Tunable Diode-based Nonlinear Transmission Lines as Pulse Shaping Networks for Microwave Systems at Megawatt Peak Powers
(2023)The pulsed power community is actively concentrating on the miniaturization of high-power microwave (HPM) systems, driven by the growing demand for applications on oceanic vessels, satellites, and unmanned aerial vehicles. ... -
Confounding Changes: Collected Poems
(2023)ABSTRACT This is a collection of poems addressing how to live as a problem solver in a dangerous world. I am aware of two planet-sized existential crises—climate and nuclear war. I trained as an environmental educator in ... -
Hell Hath No Fury, Book One of the Divine Dramedy
(2023)This thesis is the first and partial second draft of my fiction novel which I have written throughout my time as a graduate student at the University of Missouri-Kansas City Master of Fine Arts program. This work tells the ... -
Comparing a Two-Dimensional and Three-Dimensional Assessment of Unilateral Alveolar Cleft Repairs: A Pilot Project
(2023)This study compared the results of a two-dimensional (2D) and three-dimensional (3D) analysis of unilateral alveolar cleft repairs with regards to the percentage of bone fill and an associated bone fill score. Ten sets of ... -
Clinical Acceptability of Digital Indirect Bonding Compared to Direct Bonding by Varying Orthodontic Experience: Pilot Study
(2023)This pilot study was a two-factor, in-vitro pilot study comparing the clinical acceptability of orthodontic bracket placement between digital indirect and direct bonding techniques and between participants with three levels ... -
Clinical Acceptability of Digital Indirect Bonding Compared to Direct Bonding by Varying Orthodontic Experience: Pilot Study
(2023)This pilot study was a two-factor, in-vitro pilot study comparing the clinical acceptability of orthodontic bracket placement between digital indirect and direct bonding techniques and between participants with three levels ... -
Deep Learning for Handwritten Text Recognition in Historical Documents
(2023)Recognizing handwritten text in historical documents using deep learning techniques poses significant challenges in the document analysis and recognition domain. Factors such as the variability and complexity of handwriting ... -
ASSESSMENT OF A REAL-TIME OPTIMAL COUPLING FREQUENCY MEASUREMENT SYSTEM IN COMPLEX ELECTRONIC DEVICES
(2023)The work provided in this thesis focuses on the development of an at-range tech- nique to identify optimal resonant frequencies of complex electronic devices. Prior to this work, the technique had shown promise at effectively ... -
HIGH POWER MICROWAVE WEAPONS FOR COUNTER UNMANNED AERIAL SYSTEMS: EXAMINING WEAPON TARGET ALLOCATION THROUGH SIMULATED ENGAGEMENTS
(2023)The rapid advancements in technology and increase in affordability have made unmanned aerial systems (UAS) a serious threat to military operations. Dealing with these UAS using convention air defense weapons can be costly ... -
Discovery of a Novel PI3K Inhibitor for Advanced Prostrate Cancer Therapy
(2023)Prostate cancer remains a significant global health burden, especially in its advanced stages where survival rates significantly decrease. This study aimed to discover a novel therapeutic candidate that targets the ... -
ESSAYS ON LABOR, MONEY, AND CAPITAL
(2023)An aging workforce and population decline give opportunity to increase the share of employee-owner managed firms in the U.S., such as employee stock ownership plans. This demographic shift is multifactor, with falling ...