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    • University of Missouri-Columbia
    • Graduate School - MU Theses and Dissertations (MU)
    • Theses and Dissertations (MU)
    • Dissertations (MU)
    • 2009 Dissertations (MU)
    • 2009 MU dissertations - Freely available online
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    Frequency domain fluorescent molecular tomography and molecular probes for small animal imaging

    Kujala, Naresh Gandhi, 1975-
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    [PDF] research.pdf (2.025Mb)
    Date
    2009
    Format
    Thesis
    Metadata
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    Abstract
    In this thesis, we have developed a frequency domain fluorescent molecular tomographic system based on the heterodyne technique using a single source and detector pair for small animal imaging. In our system, the intensity of laser source is modulated to produce a diffuse photon density wave in the tissue. The phase of the diffuse photon density wave is measured by comparing the reference signal with the signal from tissue by using a phasemeter. In parallel, we have developed and evaluated fluorescent Alexa Fluor 680 and Alexa Fluor 750-Bombesin (BBN) probes to target gastrin-releasing peptide (GRP) receptors on prostate and breast cancer for optical molecular imaging. Confocal fluorescence microscopic imaging of the molecular probes for in vitro PC-3 prostate and T-47D breast cancer cell lines indicated specific uptake, internalization and receptor blocking of these probes. In vivo investigations in severely compromised immunodeficient (SCID) mice bearing xenografted PC-3 prostate and T47-D breast cancer lesions demonstrated the ability of this new molecular probes to specifically target tumor tissue with a high selectively and affinity.
    URI
    https://hdl.handle.net/10355/7021
    https://doi.org/10.32469/10355/7021
    Degree
    Ph. D.
    Thesis Department
    Physics (MU)
    Rights
    OpenAccess.
    This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 License.
    Collections
    • 2009 MU dissertations - Freely available online
    • Physics and Astronomy electronic theses and dissertations (MU)

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