[-] Show simple item record

dc.contributor.advisorYu, Ping, 1962 December-eng
dc.contributor.authorKujala, Naresh Gandhi, 1975-eng
dc.date.issued2009eng
dc.date.submitted2009 Summereng
dc.descriptionTitle from PDF of title page (University of Missouri--Columbia, viewed on Feb 26, 2010).eng
dc.descriptionThe entire thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file; a non-technical public abstract appears in the public.pdf file.eng
dc.descriptionDissertation advisor: Dr. Ping Yu.eng
dc.descriptionVita.eng
dc.descriptionPh.D. University of Missouri--Columbia 2009.eng
dc.description.abstractIn this thesis, we have developed a frequency domain fluorescent molecular tomographic system based on the heterodyne technique using a single source and detector pair for small animal imaging. In our system, the intensity of laser source is modulated to produce a diffuse photon density wave in the tissue. The phase of the diffuse photon density wave is measured by comparing the reference signal with the signal from tissue by using a phasemeter. In parallel, we have developed and evaluated fluorescent Alexa Fluor 680 and Alexa Fluor 750-Bombesin (BBN) probes to target gastrin-releasing peptide (GRP) receptors on prostate and breast cancer for optical molecular imaging. Confocal fluorescence microscopic imaging of the molecular probes for in vitro PC-3 prostate and T-47D breast cancer cell lines indicated specific uptake, internalization and receptor blocking of these probes. In vivo investigations in severely compromised immunodeficient (SCID) mice bearing xenografted PC-3 prostate and T47-D breast cancer lesions demonstrated the ability of this new molecular probes to specifically target tumor tissue with a high selectively and affinity.eng
dc.description.bibrefIncludes bibliographical referenceseng
dc.format.extentxv, 111 pageseng
dc.identifier.oclc607526334eng
dc.identifier.urihttps://hdl.handle.net/10355/7021
dc.identifier.urihttps://doi.org/10.32469/10355/7021eng
dc.languageEnglisheng
dc.publisherUniversity of Missouri--Columbiaeng
dc.relation.ispartofcommunityUniversity of Missouri--Columbia. Graduate School. Theses and Dissertationseng
dc.rightsOpenAccess.eng
dc.rights.licenseThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 License.
dc.subject.lcshMolecular probeseng
dc.subject.lcshAnimal models in researcheng
dc.subject.lcshImaging systems in biologyeng
dc.subject.lcshImaging systems in medicineeng
dc.subject.lcshTomography, Emissioneng
dc.subject.lcshFluorescence spectroscopyeng
dc.titleFrequency domain fluorescent molecular tomography and molecular probes for small animal imagingeng
dc.typeThesiseng
thesis.degree.disciplinePhysics (MU)eng
thesis.degree.grantorUniversity of Missouri--Columbiaeng
thesis.degree.levelDoctoraleng
thesis.degree.namePh. D.eng


Files in this item

[PDF]
[PDF]
[PDF]

This item appears in the following Collection(s)

[-] Show simple item record