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dc.contributor.authorTilghman, Brandoneng
dc.contributor.corporatenameUniversity of Missouri-Columbia. Office of Undergraduate Researcheng
dc.contributor.meetingnameUndergraduate Research and Creative Achievements Forum (2004 : University of Missouri--Columbia)eng
dc.date.issued2004eng
dc.descriptionAbstract only availableeng
dc.descriptionFaculty Mentor: Dr. George Kracke, Anesthesiologyeng
dc.description.abstractKetamine is an intravenous anesthetic agent and analgesic that has been shown to interact with the mu opioid receptor. Since reports differ in showing that ketamine is either an agonist or antagonist at the mu opioid receptor, we tried to find conditions under which we could demonstrate both of these properties of ketamine. Rat opioid receptors and potassium channels were expressed in Xenopus frog oocytes and different concentrations of ketamine were tested for agonist and antagonist effects on these receptors. We found that ketamine acts as an agonist at the mu opioid receptor. However, it acts as an antagonist when either the endogenous opioid, DAMGO, or the clinically used analgesic drug, morphine, was present. Both the agonist and antagonist effects were observed at concentrations of ketamine at or below those measured clinically in the plasma during anesthesia. The desensitizations of DAMGO and morphine activations of the mu opioid receptors were studied in the presence and absence of ketamine. It was found that regardless of the combination, all of the desensitization rates were similar. Naloxone, an antagonist at the mu opioid receptor, blocked the ketamine, morphine, and DAMGO responses thus providing additional evidence that ketamine activates this receptor. These results suggest that ketamine interacts with the opioid receptor and this interaction may partially explain its anesthetic and analgesic effects.eng
dc.description.sponsorshipLife Sciences Undergraduate Research Opportunity Programeng
dc.identifier.urihttp://hdl.handle.net/10355/706eng
dc.publisherUniversity of Missouri--Columbia. Office of Undergraduate Researcheng
dc.relation.ispartof2004 Undergraduate Research and Creative Achievements Forum (MU)eng
dc.relation.ispartofcommunityUniversity of Missouri-Columbia. Office of Undergraduate Research. Undergraduate Research and Creative Achievements Forumeng
dc.subjectagonist effecteng
dc.subjectantagonist effecteng
dc.subjectanesthesiaeng
dc.subjectdesensitization rateseng
dc.titleInvestigation of the properties of ketamine on rat Mu opioid receptors expressed in Xenopus frog oocytes [abstract]eng
dc.typeAbstracteng


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