Shared more. Cited more. Safe forever.
    • advanced search
    • submit works
    • about
    • help
    • contact us
    • login
    View Item 
    •   MOspace Home
    • University of Missouri-Columbia
    • Graduate School - MU Theses and Dissertations (MU)
    • Theses and Dissertations (MU)
    • Dissertations (MU)
    • 2018 Dissertations (MU)
    • 2018 MU dissertations - Freely available online
    • View Item
    •   MOspace Home
    • University of Missouri-Columbia
    • Graduate School - MU Theses and Dissertations (MU)
    • Theses and Dissertations (MU)
    • Dissertations (MU)
    • 2018 Dissertations (MU)
    • 2018 MU dissertations - Freely available online
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.
    advanced searchsubmit worksabouthelpcontact us

    Browse

    All of MOspaceCommunities & CollectionsDate IssuedAuthor/ContributorTitleIdentifierThesis DepartmentThesis AdvisorThesis SemesterThis CollectionDate IssuedAuthor/ContributorTitleIdentifierThesis DepartmentThesis AdvisorThesis Semester

    Statistics

    Most Popular ItemsStatistics by CountryMost Popular AuthorsStatistics by Referrer

    Functional recovery of the microcirculation during skeletal muscle regeneration

    Fernando, Charmain Angela
    View/Open
    [PDF] FernandoCharmain.pdf (8.523Mb)
    Date
    2018
    Format
    Thesis
    Metadata
    [+] Show full item record
    Abstract
    Skeletal muscle has a remarkable capacity to regenerate following injury, and although muscle regeneration has been studied extensively, little is known about the recovery of the skeletal muscle microcirculation during regeneration. To determine the restoration of blood flow regulation during skeletal muscle regeneration, this dissertation explored the recovery of vasomotor responses to physiological agonists and of functional vasodilation in response to muscle contraction. A novel injury model in the mouse gluteus maximus muscle was developed to study the microcirculation in vivo using intravital microscopy at welldefined time points (5, 10, 21 and 35 days) post injury compared to uninjured Control muscles. Studies encompassed feed arteries and the principal branches (1st, 2nd and 3rd order) of arteriolar networks comprising the resistance vasculature. Vasomotor responses to agonists and active force developed by muscle fibers recovered by 21d, however functional vasodilation required [about]35d to recover. This research provides novel insight into when and to what extent blood flow regulation is restored during skeletal muscle regeneration and provides novel perspective towards developing therapeutic strategies for restoring skeletal muscle function during recovery from injury.
    URI
    https://hdl.handle.net/10355/70701
    https://doi.org/10.32469/10355/70701
    Degree
    Ph. D.
    Thesis Department
    Medical pharmacology and physiology (MU)
    Rights
    OpenAccess
    This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 License
    Collections
    • Medical Pharmacology and Physiology electronic theses and dissertations (MU)
    • 2018 MU dissertations - Freely available online

    Send Feedback
    hosted by University of Missouri Library Systems
     

     


    Send Feedback
    hosted by University of Missouri Library Systems