What antiepileptic drugs cause elevation of liver transaminases?
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Essentially all antiepileptic medications can raise liver enzymes or cause hepatoxicity as a rare side effect; “periodic” liver enzyme monitoring is recommended. (SOR C, based on expert opinion.) However, valproate and felbamate are associated with higher rates of hepatic failure (SOR B, based on cohort studies) and have specific liver function monitoring recommendations.
Evidence Based Practice 11(2): 04.