What treatments are safe and effective for vitiligo?
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Class III topical corticosteroids are effective for localized vitiligo in adults and children. Optimum treatment of generalized vitiligo is less clear. Topical steroids are effective, but their long-term use is limited by adverse effects. Oral methoxsalen, oral trioxsalen, and oral psoralen (all plus sunlight) are effective, but also limited by adverse effects. (SOR A, based on 2 meta-analyses). Tacrolimus is an effective alternative for children with localized vitiligo (SOB B, based on a single randomized controlled trial [RCT]), but concerns persist about its long-term safety.
Evidence Based Practice 11(4): 04-05.