L-Methylfolate (Deplin®): A medical food for depression?
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Limited evidence (from before the adoption of widespread dietary supplementation of folate) suggested that folate might be beneficial in depression by augmenting the effects of antidepressants. However, no direct evidence suggests that the medical food supplement L-methylfolate (Deplin®) is the most effective form of supplementation. It is also unclear whether patients must be deficient in folate to receive benefit or whether this prescription supplement has significant clinical application in an era of widespread vitamin fortification of foods.
Evidence Based Practice 11(7): 09-10.