Does homocysteine-lowering therapy prevent cardiovascular events in adults with cardiovascular disease?
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Lowering plasma homocysteine levels with folic acid and B vitamin supplementation does not reduce the risk of myocardial infarction (MI) or cardiovascular (CV) mortality more than placebo. (SOR A, based on consistent randomized controlled trials [RCTs] and meta-analyses.)
Evidence Based Practice 11(8): 06-07.