What is the best management for percutaneous occupational exposure to HIV?
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Immediate therapy with antiretroviral medication reduces the risk of developing HIV after percutaneous occupational exposure. (SOR B, based on a case-control study.) Current guidelines recommend that 4 weeks of double- or triple-drug antiretroviral therapy be initiated as soon as possible after occupational exposure and that expert consultation be obtained. (SOR C, based on disease-oriented evidence and expert opinion.)
Evidence Based Practice 11(8): 04-05.