What is the best treatment for esophageal spasms?
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Trazodone, at doses of 100 to 150 mg/d relieves symptoms due to esophageal spasm (SOR B, based on a single randomized controlled trial [RCT]). Other therapies with less supporting evidence include calcium channel blockers, proton-pump inhibitors (PPIs), sildenafil, and botulinum toxin injections (SOR C, based on low- quality RCTs, case series, and expert opinion).
Evidence-based practice 11, no. 09 (2008): 04-05