Do oral hypoglycemic agents reduce mortality in type 2 diabetes?
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Metformin reduces all-cause mortality when used to treat patients with type 2 diabetes who are overweight. (SOR A, based on a meta-analysis and large randomized controlled trials [RCTs].) The effect of thiazolidinediones (TZDs) on mortality is less clear (meta-analyses have heterogeneous outcomes), and further studies are warranted.
Evidence Based Practice 11(10): 05-07.