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TRPV4 contributes to stretch-induced hypercontractility and time-dependent dysfunction in the aged heart

URI
https://hdl.handle.net/10355/73833
https://doi.org/10.32469/10355/73833
dc.contributor.advisorDomeier, Timothy L.eng
dc.contributor.authorVeteto, Adam Bruceeng
dc.date.issued2019eng
dc.date.submitted2019 Springeng
dc.description.abstract[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Aims: Cardiovascular disease remains the greatest cause of mortality in Americans over 65. The stretch-activated Transient Receptor Potential Vanilloid-4 (TRPV4) ion channel is expressed in cardiomyocytes of the aged heart. This investigation tests the hypothesis that TRPV4 alters calcium handling and cardiac function in response to increased ventricular preload and cardiomyocyte stretch.eng
dc.description.bibrefIncludes bibliographical references.eng
dc.format.extentix, 95 pages : illustrationeng
dc.identifier.urihttps://hdl.handle.net/10355/73833
dc.identifier.urihttps://doi.org/10.32469/10355/73833eng
dc.languageEnglisheng
dc.publisherUniversity of Missouri--Columbiaeng
dc.relation.ispartofcommunityUniversity of Missouri--Columbia. Graduate School. Theses and Dissertationseng
dc.rightsAccess to files is limited to the University of Missouri--Columbia.eng
dc.rights.licenseThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 License.
dc.subject.otherPharmacologyeng
dc.subject.otherBiologyeng
dc.subject.otherCardiovascular system--Diseaseseng
dc.titleTRPV4 contributes to stretch-induced hypercontractility and time-dependent dysfunction in the aged hearteng
dc.typeThesiseng
thesis.degree.disciplineMedical pharmacology and physiology (MU)eng
thesis.degree.grantorUniversity of Missouri--Columbiaeng
thesis.degree.levelDoctoraleng
thesis.degree.namePh. D.eng


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