Potential links between arterial and venous clotting disorders
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Venous thromboembolic disorders (including deep venous thrombosis [DVT] and pulmonary embolism [PE]) appear to be clinically distinct processes from thrombotic atherosclerotic diseases (leading to myocardial infarction [MI] and stroke). This distinction is supported by the pathophysiology of each condition: venous thrombi consist of predominantly red cells and fibrin, whereas arterial thrombi consist primarily of platelets. However, new research underscores important similarities. The occurrence of one syndrome is associated with an increased incidence of the other; both appear to share several lifestyle risk factors; and genetic disorders are being identified that may contribute to both venous and arterial thrombosis. The rigid distinction between arterial and venous clotting disorders is being revised.
Evidence-based practice 11, no. 11 (2008): 01-02