What is the relative effectiveness and safety of second-generation antidepressants?
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While some small differences have been found between agents, selective serotonin reuptake inhibitors (SSRIs) and non-SSRI second-generation antidepressants generally have similar efficacy and discontinuation rates when used to treat depression. However, side effect profiles differ by agent: more blood pressure elevation with venlafaxine, more weight gain with mirtazapine, and less sexual dysfunction with bupropion. (SOR A, based on systematic reviews and meta-analyses.)
Evidence Based Practice 11(12): 06-07.