What is the best prophylaxis for menstrual migraine?
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Oral naratriptan results in slightly fewer headache days than placebo in patients with menstrual migraines. (SOR A, based on consistent randomized controlled trials [RCTs].) Naproxen and magnesium therapy are also more effective than placebo. (SOR B, based on single small RCTs.) Frovatriptan may reduce the severity of pain better than transdermal estrogens and naproxen (SOR C, based on a single open-label comparison study), but has not been studied in comparison with a placebo.
Evidence Based Practice 11(12): 04.