Recent Submissions

  • What are the indications for cardiac CT angiography in the evaluation of coronary artery disease? 

    Jafrey, Suhail; Satre, Thomas J. (Family Physicians Inquiries Network, 2009-12)
    Cardiac computed tomography angiography (CCTA) may be considered in the evaluation of symptomatic patients with intermediate pretest probability of coronary artery disease (CAD) and without previous revascularization, if ...
  • What is the efficacy and safety of sinecatechins and imiquimod when treating genital and perianal warts? 

    Schobert, Josephine; Kraus, Connie (Family Physicians Inquiries Network, 2009-12)
    Sinecatechins (Veregen®) and imiquimod (Aldara®) produce comparable clearance rates in the treatment of patients with anogenital warts. Itching, the most common local side effect of either agent, is more common with ...
  • Warfarin therapy not warranted for secondary prevention of CVD 

    Wong, Long; Criswell, Dan (Family Physicians Inquiries Network, 2009-12)
    No data are available to support the addition or substitution of warfarin after failure of antiplatelet agents for secondary prevention of ischemic stroke. Further, warfarin may be no better than placebo at reducing the ...
  • Is there a role for CA-125 in the evaluation of abdominal pain? 

    Campbell, Robert J.; Nagy, Suzanne; Lagergren, Emily (Family Physicians Inquiries Network, 2009-12)
    CA-125 testing is not specific enough in the primary evaluation of abdominal pain to be clinically useful, and would have unacceptably high false-positive rates. (SOR B, based on retrospective studies and reviews.) CA-125 ...
  • Party wherever you are 

    Neher, Jon O. (Family Physicians Inquiries Network, 2009-12)
    This letter from the editor of Evidence Based Practice wished readers well in the new year.
  • Is calcitonin useful for reducing the pain of acute osteoporotic fractures? 

    Parker, Alex; Soberon, Angelica M.; Rodriguez, Jose E. (Family Physicians Inquiries Network, 2009-12)
    Calcitonin has been shown to improve acute pain at rest in patients with osteoporotic vertebral fractures, when compared with placebo, and reduce the use of other analgesic medications (SOR A, based on a meta-analysis of ...
  • Is antiviral therapy for acute, localized herpes zoster safe and effective? 

    Abello-Poblete, Maria Veronica; Remde, Alan (Family Physicians Inquiries Network, 2009-12)
    Oral famciclovir, valacyclovir, and acyclovir are all well tolerated and accelerate resolution of pain associated with subacute herpetic neuralgia (SHN) in patients 50 years of age or older (SOR A, multiple randomized ...
  • For the initial management of dyspepsia, what strategy is best to prevent recurrent dyspepsia/gastritis? 

    Scroggins, Brent; Over, Darrell R. (Family Physicians Inquiries Network, 2009-12)
    It appears there is little difference in efficacy at 1 year between a Helicobacter pylori “test-and-treat” strategy and empiric proton-pump inhibitor (PPI) treatment for initial management of patients with dyspepsia, even ...
  • Infants, Toddlers, and Fruit Juice 

    Family Physicians Inquiries Network (Family Physicians Inquiries Network, 2009-12)
    It is exciting to introduce new foods to your infant and watch as they react to new flavors. Infants and toddlers usually love fruit juices and fruit drinks. They often start asking for juice while still nursing or drinking ...
  • How well do BNP levels correspond to response of CHF to therapy? 

    Chadsey, Malinda; Over, Darrell R. (Family Physicians Inquiries Network, 2009-12)
    B-type natriuretic peptide (BNP)-guided therapy does not alter all-cause hospitalization rates, quality of life, or overall survival compared with symptom-guided therapy, although it does appear to reduce the rate of ...
  • How do you prevent MRSA colonization among close contacts of patients with MRSA skin and soft tissue infections? 

    Taylor, Randolph II; Gauer, Robert (Family Physicians Inquiries Network, 2009-12)
    Standard hand hygiene and contact precautions help prevent methicillin-resistant Staphylococcus aureus (MRSA) infection colonization among close contacts of patients with MRSA skin infections. (SOR C, based on expert ...
  • Does giving Lactobacillus to children at the same time antibiotics are started reduce the incidence of Clostridium difficile-associated diarrhea? 

    KenKnight, Jonathan; Power, David V. (Family Physicians Inquiries Network, 2009-12)
    Probiotics appear to prevent all-cause antibiotic-associated diarrhea (AAD) in children. (SOR B, based on heterogeneous randomized controlled trials [RCTs].) However, the effect of probiotics on C difficile-associated ...
  • Will Overweight Children Become Overweight Adults? 

    Family Physicians Inquiries Network (Family Physicians Inquiries Network, 2009-11)
    Unfortunately, studies show many overweight children will become overweight or obese adults. In fact, 1 out of every 3 children is now considered overweight or obese in the United States.
  • When is medication appropriate for chronic insomnia? 

    Ho, Nam; Satre, Thomas J. (Family Physicians Inquiries Network, 2009-11)
    Medications are an appropriate second-line treatment if a behavioral intervention is not effective and any comorbid conditions, medications, or substances that might interfere with sleep have been identified and addressed ...
  • What is the best treatment of recurrent aphthous ulcers? 

    McCarthy, Claire; Bailey, Justin (Family Physicians Inquiries Network, 2009-11)
    Amlexanox 5% paste significantly reduces ulcer size and duration of pain, and increases speed of healing. (SOR A, based on multiple randomized controlled trials [RCTs].) Topical silver nitrate and corticosteroids reduce ...
  • What is the best treatment for chronic post-CABG pain? 

    Hutchinson, Carrie; Merok, Joshua R. (Family Physicians Inquiries Network, 2009-11)
    Evidence is insufficient to choose a single best agent for chronic post-CABG pain. However, amitriptyline, capsaicin cream, opioids, and NMDA antagonists are effective choices for other postsurgical pain syndromes and may ...
  • What is the best treatment for migraines during pregnancy? 

    Swenson, Amanda; Schrager, Sarina B. (Family Physicians Inquiries Network, 2009-11)
    Little evidence supports the use of 1 treatment over another for migraines in pregnant women. There are no Cochrane reviews or American College of Obstetricians and Gynecologists Practice Bulletins on the topic. Experts ...
  • What is the best treatment for an adult with an umbilical hernia? 

    Castro, Robert; Rodriguez, Jose E. (Family Physicians Inquiries Network, 2009-11)
    The laparoscopic onlay patch repair is associated with less recurrence, shorter hospital stay, lower wound morbidity, and lower postoperative pain when compared with open suture repair. (SOR B, based on a single cohort ...
  • When is heparin indicated for the management of acute stroke? 

    Murphy, Shelley; Rodriguez, Jose E. (Family Physicians Inquiries Network, 2009-12)
    Heparin does not appear to improve overall outcomes when used for ischemic stroke or within the first 2 weeks of a cardioembolic stroke. (SOR B, extrapolated from meta-analyses of multiple heparinoids.)
  • What is the best way to screen for major depressive disorder in patients with dementia? 

    Tsai, Elizabeth H.; Levine, Jeffrey P.; Roemheld-Hamm, Beatrix (Family Physicians Inquiries Network, 2009-12)
    The Cornell Scale for Depression in Dementia (CSDD) is a relatively accurate and well- studied screening tool for depression in patients with dementia. (SOR A, based on validating cohort studies.)

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