• Are selective serotonin reuptake inhibitors (SSRIs) safe in pregnancy? 

    Oleszkowicz, Andrew; Dresang, Lee T. (Family Physicians Inquiries Network, 2009-07)
    SSRIs have been accepted by many as the treatment of choice for depression in pregnancy. Overall use of SSRIs in the first trimester is not associated with congenital malformations, but 2 SSRIs (sertraline and paroxetine) ...
  • How can we best manage chronic pain for patients taking long-term narcotic analgesics? 

    Glass, Gina G. (Family Physicians Inquiries Network, 2009-07)
    Tramadol has proven efficacy up to 6 months and less abuse potential than hydrocodone over 1 year. (SOR B, based on randomized controlled trials [RCTs].) Transdermal fentanyl and sustained-release morphine have been proven ...
  • Is lithium an effective augmentation agent for treatment-resistant depression? 

    Durme, Daniel J. van; Box, Stephenie (Family Physicians Inquiries Network, 2009-03)
    Antidepressant augmentation with lithium (600-800 mg/d or a dose sufficient to achieve serum concentrations of ≥0.5 mEq/L) may increase recovery rates in treatment-resistant depression (TRD). (SOR B, based on meta-analyses ...
  • What is the optimal treatment duration for depression? 

    David, Larry; Kraus, Connie (Family Physicians Inquiries Network, 2009-04)
    Continuing the medical therapy for depression for 1 to 2 years after acute therapy reduces the rates of relapse (return of symptoms during remission) and recurrence (new episode after recovery). (SOR A, based on 2 meta-analyses ...