Is the combined use of bupropion and nicotine replacement therapy (NRTRT) more clinically effective than either agent alone for smoking cessation?
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The combination of NRT plus bupropion is more effective than NRT, but no better than bupropion alone for smoking cessation. (SOR B, based on a randomized controlled trial.) Combination therapy is not recommended for smoking cessation. (SOR C, based on a practice guideline.)
Evidence Based Practice 12(1): 06.