Is olanzapine plus fluoxetine more effective than olanzapine alone for bipolar I depression?
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The combination of olanzapine (Zyprexa®) plus fluoxetine (Prozac®) is more effective for improving depression symptoms in patients with bipolar disorder type I than olanzapine monotherapy. However, the combination is comparable in effectiveness to lamotrigine (Lamictal®) monotherapy. (SOR B, based on a single randomized trial for each comparison.)
Evidence Based Practice 12(2): 11.