Is olanzapine plus fluoxetine more effective than olanzapine alone for bipolar I depression?
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The combination of olanzapine (Zyprexa??) plus fluoxetine (Prozac??) is more effective for improving depression symptoms in patients with bipolar disorder type I than olanzapine monotherapy. However, the combination is comparable in effectiveness to lamotrigine (Lamictal??) monotherapy. (SOR B, based on a single randomized trial for each comparison.)
Evidence-based practice 12, no. 02 (2009): 11