What are the prognostic implications of elevated troponin I in acute coronary syndrome?
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A positive troponin I assay (>0.1 μg/L) drawn from a patient with acute coronary syndrome (ACS) is a reliable predictor of adverse short-term outcomes, specifically death or myocardial infarction (MI). (SOR A, based on multiple randomized controlled trials [RCTs].) However, a negative troponin I assay at presentation does not reliably predict a good outcome, as the short-term event rates (death or MI) still approach 6% (SOR B, based on 1 RCT).
Evidence Based Practice 12(2): 09+.