What is the best medication for gastrointestinal stress ulcer prophylaxis?
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For reducing stress ulcers in intensive care unit (ICU) patients, a proton pump inhibitor (PPI) is better than a histamine-2 (H2) blocker (SOR B, based on heterogeneous reviews and randomized controlled trials [RCTs]). Sucralfate is not beneficial (SOR A, based on a meta-analysis).
Evidence Based Practice 12(2): 04-05.