Is lithium an effective augmentation agent for treatment-resistant depression?
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Antidepressant augmentation with lithium (600-800 mg/d or a dose sufficient to achieve serum concentrations of ≥0.5 mEq/L) may increase recovery rates in treatment-resistant depression (TRD). (SOR B, based on meta-analyses of small randomized controlled trials [RCTs].)
Evidence Based Practice 12(3): 05.