Large trial finds adding an ARB to an ACE-I does not help diabetic nephropathy
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While some evidence suggests that combining angiotensin converting-enzyme inhibitors (ACE-Is) and angiotensin receptor blockers (ARBs) might have clinically important benefits in some situations (particularly for patients with severe congestive heart failure [CHF]), a recent large randomized controlled trial (RCT) recently found no tangible benefit to combination therapy in patients with diabetes or arteriosclerotic cardiovascular disease without heart failure.
Evidence-based practice 12, no. 04 (2009): 01-02