In outpatients dependent on benzodiazepines, what medications can increase discontinuation rates?
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Along with a gradual benzodiazepine taper, the addition of imipramine or carbamazepine may result in higher discontinuation rates. Potential adjunct medications that have not shown benefit include propranolol, trazodone, dothiepin, hydroxyzine, buspirone, and progesterone. (SOR B, based on small randomized controlled trials [RCTs].)
Evidence Based Practice 12(5): 04.