Are selective serotonin reuptake inhibitors (SSRIs) safe in pregnancy?
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SSRIs have been accepted by many as the treatment of choice for depression in pregnancy. Overall use of SSRIs in the first trimester is not associated with congenital malformations, but 2 SSRIs (sertraline and paroxetine) have been associated with omphalocele and congenital cardiac defects when given in the first trimester. Use of SSRIs in the third trimester has been associated with neonatal withdrawal syndrome.
Evidence Based Practice 12(7): 14.