What is the most appropriate management when myalgia develops in a patient taking a statin?
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Patients who present with intolerable myalgia but a normal creatine kinase (CK) should discontinue statin therapy. When symptoms resolve, the physician can restart the same statin at a lower dose or attempt a different statin. (SOR C, based on expert opinion.) If low-density lipoprotein cholesterol (LDL-C) concentration is not at goal with reduced dosing or with the new statin, consider adding other active agents. (SOR C, based on expert opinion.)
Evidence Based Practice 12(8): 08.