What is the best way to manage immunizations in patients on immunosuppressive therapy?
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When feasible, necessary vaccines should be administered prior to initiation of chemotherapy, radiation, splenectomy, or administration of immunosuppressive drugs. Immunosuppressed patients should not receive live vaccines. Inactivated or killed vaccines are safe, but efficacy may be significantly reduced. Household members and close contacts of immunosuppressed patients may receive all age-appropriate vaccines, with the exception of live oral polio vaccine (OPV) and smallpox vaccine. (SOR C, based on expert opinion.)
Evidence Based Practice 12(9): 13.