Does the initiation of an SSRI for depression increase the risk of adult suicide?
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In adults, selective serotonin reuptake inhibitors (SSRIs) have not been shown to increase the risk of completed suicide. (SOR A, based on systematic reviews.) Studies conflict on a possible association between SSRI initiation and suicide attempts. However, no difference has been found in the risk of attempted or completed suicide among adults prescribed SSRIs versus tricyclic antidepressants. (SOR A, based on systematic reviews and case-control studies.)
Evidence Based Practice 12(10): 13.