Does long-term celecoxib use increase the risk of myocardial infarction?
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There is an overall increased risk of myocardial infarction (MI) with long-term use of cyclo-oxygenase-2 (COX-2) inhibitors (coxibs) compared with other nonsteroidal anti-inflammatory drugs (NSAIDs) or placebo. Celecoxib (Celebrex®), however, does not appear to increase MI rates over placebo, particularly when dosed ≤200 mg/d. (SOR A, based on a systematic review.)
Evidence Based Practice 12(10): 09.