How safe and effective is methylphenidate for major depression in the elderly?
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Methylphenidate at doses of 10 to 60 mg/d is an effective monotherapy for depressed medically ill and poststroke elderly patients older than 70 years. (SOR A, based on multiple homogeneous randomized controlled trials [RCTs]). Methylphenidate also reduces time to clinical response in elderly patients taking citalopram. (SOR B, based on 1 small RCT.) Current evidence suggests minimal significant adverse effects.
Evidence Based Practice 12(10): 14-15.