New evidence supports vitamin D supplementation to reduce the risk fractures in patients over 65
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Numerous studies have focused on the effectiveness of calcium for fracture reduction, while studies on vitamin D alone have been limited. A 2007 review of 15 randomized controlled trials (RCTs) by the Agency for Healthcare Research and Quality found inconsistent evidence that vitamin D supplementation (in doses ranging from 300 to 2,000 IU/d) leads to decreased fracture risk. A large meta-analysis in 2007 demonstrated a decreased risk of hip fracture with calcium and vitamin D together, but did not find a benefit with vitamin D alone.
Evidence-based practice 12, no. 10 (2009): 01-02