What is the risk of CHF and CV death associated with the use of pioglitazone?
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Pioglitazone use may be associated with a small (<2%) increased risk of nonfatal heart failure. (SOR B, based on heterogenous meta-analyses.) There is no adverse effect on cardiovascular death rates. (SOR A, based on consistent meta-analyses.)
Evidence Based Practice 12(10): 11-12.