What is the best treatment of recurrent aphthous ulcers?
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Amlexanox 5% paste significantly reduces ulcer size and duration of pain, and increases speed of healing. (SOR A, based on multiple randomized controlled trials [RCTs].) Topical silver nitrate and corticosteroids reduce pain. (SOR B, based on multiple RCTs.) Chlorhexidine mouthwash reduces overall ulcer burden. (SOR B, based on heterogeneous RCTs.) “Magic mouthwash” is as effective as saline baking soda washes. (SOR B, based on a single RCT.) Nonpharmacologic interventions include avoiding trauma, avoidance of acidic foods/beverages, and minimizing stress. (SOR C, based on expert opinion.)
Evidence Based Practice 12(11): 07-08.