Does giving Lactobacillus to children at the same time antibiotics are started reduce the incidence of Clostridium difficile-associated diarrhea?
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Probiotics appear to prevent all-cause antibiotic-associated diarrhea (AAD) in children. (SOR B, based on heterogeneous randomized controlled trials [RCTs].) However, the effect of probiotics on C difficile-associated diarrhea (CDAD) in children is unclear. Further evidence regarding the relative efficacy of the various probiotic agents and dosing are required before a general recommendation can be made regarding their use.
Evidence Based Practice 12(12): 10.