Is antiviral therapy for acute, localized herpes zoster safe and effective?

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Is antiviral therapy for acute, localized herpes zoster safe and effective?

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Title: Is antiviral therapy for acute, localized herpes zoster safe and effective?
Author: Abello-Poblete, Maria Veronica; Remde, Alan
Keywords: pain control
pain resolution
Date: 2009-12
Publisher: Family Physicians Inquiries Network
Citation: Evidence Based Practice 12(12): 14.
Series/Report no.: Help Desk Answers
Abstract: Oral famciclovir, valacyclovir, and acyclovir are all well tolerated and accelerate resolution of pain associated with subacute herpetic neuralgia (SHN) in patients 50 years of age or older (SOR A, multiple randomized controlled trials [RCTs]). However, acyclovir was found to have no significant effect in reducing postherpetic neuralgia (PHN) at 4 and 6 months (SOR A, based on a high-quality meta-analysis), and evidence is insufficient to determine whether famciclovir or valacyclovir reduce PHN.
URI: http://hdl.handle.net/10355/7649

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