Is antiviral therapy for acute, localized herpes zoster safe and effective?
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Oral famciclovir, valacyclovir, and acyclovir are all well tolerated and accelerate resolution of pain associated with subacute herpetic neuralgia (SHN) in patients 50 years of age or older (SOR A, multiple randomized controlled trials [RCTs]). However, acyclovir was found to have no significant effect in reducing postherpetic neuralgia (PHN) at 4 and 6 months (SOR A, based on a high-quality meta-analysis), and evidence is insufficient to determine whether famciclovir or valacyclovir reduce PHN.
Evidence-based practice 12, no. 12 (2009): 14