What is the value of intensive statin therapy in lowering morbidity and mortality in patients at high risk for coronary artery disease?
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High-dose statins are better at prolonging the time to the first cardiovascular event in patients with diabetes and chronic kidney disease, but not in patients with diabetes who have normal kidney function. (SOR B, based on a randomized controlled trial.) High-dose statin therapy reduces the risk of myocardial infarction (MI) and stroke in patients with either acute coronary syndromes (ACS) or stable coronary artery disease (CAD), and has been demonstrated to reduce all-cause mortality in patients with ACS. (SOR A, based on a meta-analysis.)
Evidence-based practice 12, no. 12 (2009): 07-08