Diagnosing Von Willebrand Disease
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The diagnosis of vWD requires two clinical criteria: (1) a personal history, family history, or physical evidence of mucocutaneous bleeding and (2) a qualitative or quantitative decrease in functional activity of von Willebrand factor (vWF). (Strength of Recommendation [SOR]: C, based on expert opinion). Some patients with borderline decreased functional activity of vWF will meet the criteria for vWD if the other clinical criterion is present. (SOR: C, based on expert consensus and opinion).
American Family Physician, 81(12): 1415-1418.