Does lowering a fever >101F in children improve clinical outcomes?
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Treating fever significantly increases comfort, activity, feeding, and fluid intake and decreases the patient's temperature compared with placebo (strength of recommendation (SOR): A, multiple randomized controlled trials [RCTs]). It doesn't shorten or prolong the overall duration of illness or reduce the recurrence of febrile seizures (SOR: A, multiple RCTs). In patients with varicella, reducing fever prolongs the time it takes for lesions to crust, but doesn't appear to cause group A streptococcal necrotizing fasciitis (SOR: B, multiple prospective cohorts).
Journal of Family Practice, 59(6) 2010: 353+.