Shared more. Cited more. Safe forever.
    • advanced search
    • submit works
    • about
    • help
    • contact us
    • login
    View Item 
    •   MOspace Home
    • University of Missouri-Columbia
    • Graduate School - MU Theses and Dissertations (MU)
    • Theses and Dissertations (MU)
    • Dissertations (MU)
    • 2020 Dissertations (MU)
    • 2020 MU dissertations - Access restricted to UM
    • View Item
    •   MOspace Home
    • University of Missouri-Columbia
    • Graduate School - MU Theses and Dissertations (MU)
    • Theses and Dissertations (MU)
    • Dissertations (MU)
    • 2020 Dissertations (MU)
    • 2020 MU dissertations - Access restricted to UM
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.
    advanced searchsubmit worksabouthelpcontact us

    Browse

    All of MOspaceCommunities & CollectionsDate IssuedAuthor/ContributorTitleSubjectIdentifierThesis DepartmentThesis AdvisorThesis SemesterThis CollectionDate IssuedAuthor/ContributorTitleSubjectIdentifierThesis DepartmentThesis AdvisorThesis Semester

    Statistics

    Most Popular ItemsStatistics by CountryMost Popular AuthorsStatistics by Referrer

    Food 'four' thought : examining sigma-1 receptor antagonist PD144418 on food reinforced behaviors

    Tapia, Melissa A.
    View/Open
    [PDF] TapiaMelissa.pdf (3.568Mb)
    Date
    2020
    Format
    Thesis
    Metadata
    [+] Show full item record
    Abstract
    [ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] A large number of individuals consume a poor diet, including food and beverages that are high in fat, salts, and/or sugar, often in conjunction with a lack of exercise. Alterations in one's feeding behaviors have implications as it relates to the prevention and treatment of one's risk of obesity and of common health consequences associated with being overweight or obese. Therefore, exploring a potential pharmacological manipulation of feeding behaviors could provide a treatment option for those who have disordered eating patterns. The potent and selective sigma-1 receptor antagonist PD144418 was examined as a potential therapeutic target regarding motivational aspects of food-reinforced operant behaviors. Additionally, experiments looked at whether biological factors (i.e., sex) and physiological factors (i.e., energy intake and physical activity) moderate the effects. Results indicated PD144418 decreases an animal's motivational effort, or work, for food pellets but has no impact on the consumption of freely available food pellets. Such effects on motivational effort to work for food occur regardless of sex. However, alterations in physiological factors, such as energy intake, appear to be sex dependent as PD144418 selectively reduces female motivation for food during negative energy balance. Moreover, in males, PD144418, in conjunction with access to voluntary physical activity, does not alter food-reinforced operant responding. How PD144418 may be exerting its effects on motivational aspects of feeding is via alterations in dopaminergic signaling, as coadministration of PD144418 along with an intra-accumbens infusion of d-amphetamine, a dopamine agonist, but not DAMGO, a mu-opioid agonist attenuates operant responding.
    URI
    https://hdl.handle.net/10355/78137
    Degree
    Ph. D.
    Thesis Department
    Psychology (MU)
    Rights
    Access is limited to the campuses of the University of Missouri
    Collections
    • 2020 MU dissertations - Access restricted to UM
    • Psychological Sciences electronic theses and dissertations (MU)

    Send Feedback
    hosted by University of Missouri Library Systems
     

     


    Send Feedback
    hosted by University of Missouri Library Systems