What common food additives can cause acute, nonallergic symptoms?
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Aspartame may be associated with headaches in susceptible individuals (SOR B, based on a small crossover study.) Monosodium glutamate (MSG) is associated with a range of constitutional symptoms; however, with blinding, responses to MSG are rarely consistent. (SOR B, based on a randomized controlled trial [RCT].)
Evidence Based Practice 13(2): 05-06.