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    The effects of blast-induced traumatic brain injury on two transgenic models of Alzheimer's Disease

    Gann, Courtney L.
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    [PDF] GannCourtneyResearch.pdf (463.9Kb)
    Date
    2020
    Format
    Thesis
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    Abstract
    [ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Traumatic Brain Injury (TBI) is well known to be a risk factor for Alzheimer's Disease (AD). However, the mechanism by which TBI increases the risk of AD is still poorly understood, and research is greatly needed to explain the long-term effects of TBI. In the current study, we examined the long-term effects of a blast-induced mild TBI (mTBI) on two rat models of AD: APP21 (n=7) and APP+PS1 (n=14). We examined differences among genotype, sex, and condition (blast exposure or no blast exposure). Five months after half of the rats were exposed to a low intensity blast, behavioral assessment occurred. We examined spatial learning, memory, anxiety levels, locomotor activity, willingness to explore, and social motivation through a range of assessments. We hypothesized that the APP21 and APP+PS11rats exposed to a low intensity blast will have lower spatial learning skills, poorer memories, and will show more anxious behaviors than the APP21 and APP+PS1 rats that were not exposed to a blast. Our results showed that rats with a mTBI showed significantly more impaired memory and spatial learning skills, but no anxiety differences were found between our mTBI and the control APP21 and APP+PS1 rats.
    URI
    https://hdl.handle.net/10355/78265
    Degree
    M.A.
    Thesis Department
    Psychological sciences (MU)
    Rights
    Access to files is limited to the campuses of the University of Missouri
    This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 License. Copyright held by author.
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    • Psychological Sciences electronic theses and dissertations (MU)
    • 2020 MU theses - Access restricted to UM

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