Is any single medication for major depression superior to others?
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Although several antidepressants (particularly venlafaxine and mirtazapine) may have slightly greater early response rates (SOR B, based on heterogeneous meta-analyses), the clinical value of this effect is unknown and all newer antidepressants are thought to be similar in overall efficacy and effect on quality of life. (SOR C, based on expert opinion.) SSRIs as a class are somewhat better tolerated than tricyclic antidepressants (TCAs). (SOR A, based on a meta-analysis.)
Evidence Based Practice 13(3): 14.